Life Extension Curcumin 95, 500 mg, 60 capsules

Jarrow's Curcumin 95 is an 18:1 concentrate of the antioxidants found in the spice turmeric root. Curcumin 95 contains 95% curcuminoids, which are powerful antioxidants. Specifically, curcumin and its derivatives protect DNA against oxidative damage induced by reactive oxygen species. Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties.1-6 Curcumin is also found to increase detoxifying enzymes and promote healthy DNA function.7-11 Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body. Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body.12 Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).13,14 Other clinical trials suggest roles for curcumin in helping maintain healthy lipid profile, bowel, and joint functions.15,16 Curcumin can also help maintain normal healthy platelet function,17-20 and have immunomodulatory effects by inhibiting histamine release from mast cells.21 Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.22-28 Curcumin may effectively support pancreatic islet health.29,30 Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals,31,32 protecting against damaging free radicals, and promoting normal cell cycle growth.