Life Extension ComfortMAX, 60 AM/PM vegetarian tablets

According to the National Institutes of Health, nearly 25 million Americans experience daily discomfort.1 This kind of discomfort can affect mood, mobility and quality of life.2 The reasons for physical discomfort vary, but the way we experience that discomfort doesn’t: Our peripheral nerves are responsible for delivering sensory information (an itch, temperature change, physical pressure, etc.) to the brain. And that’s where ComfortMAX comes in. Palmitoylethanolamide (PEA) Palmitoylethanolamide (PEA) is a unique kind of fatty acid that can inhibit discomfort.3 Your body naturally produces PEA as part of a healthy inflammatory and immune response.4 In fact, PEA inhibits the secretion of compounds from mast cells, a type of white blood cell. Over time, our mast cells decrease in number, causing our remaining mast cells to work harder.5 That can make them overly sensitive, activating processes linked to nerve discomfort. By inhibiting compounds released by mast cells, PEA promotes your body’s natural response to uncomfortable nerve stimuli at the cellular level.6-8 PEA’s efficacy has been demonstrated in multiple clinical trials.9 In a randomized controlled trial following 636 patients over a period of three weeks, 600 mg of PEA every day significantly improved scores that measured relative comfort and quality of life.10 In a smaller randomized controlled trial, patients reported that PEA outperformed standard care for discomfort when taken for two weeks.11 Honokiol Honokiol is a naturally occurring lignan compound derived from several species of magnolia, many of which have been used in traditional Asian medicine for centuries.12 Now, scientists are discovering that honokiol has applications for nerve health and comfort. Honokiol has been shown to support the “calming” GABA receptors in the brain, which in turn helps alleviate discomfort.13-15 Furthermore, honokiol is quickly taken up into the brain in animal models, making it an ideal ingredient for nerve health and comfort.16,17 Innovative Daytime & Nighttime Formula ComfortMAX has been formulated to be taken twice a day, one tablet in the morning and one tablet at night, right before bed, for day and night support. Each package of ComfortMAX provides a 30-day supply.